Antabuse | Disulfiram
Antabuse's generic name is Disulfiram. Its brand name is Antabus.This medication is an aldehyde dehydrogenase inhibitor.
Antabuse is indicated for
Antabuse is used for treating alcoholism, helping recovering alcoholics abstain from drinking alcohol. It serves as physical and psychological deterrent to someone trying to stop drinking.
Antabuse works by interfering with the way the body metabolises alcohol.
Alcohol is broken down in the body to a compound called acetaldehyde. This is then normally broken down further by an enzyme in the liver called aldehyde dehydrogenase. Antabuse stops this enzyme from working. This means that when alcohol is consumed, the body cannot process it normally. Instead, acetaldehyde accumulates in the bloodstream, causing a variety of unpleasant effects (e.g., flushing, dizziness, headache, nausea and vomiting) even when a small amount of alcohol is consumed. This reaction to alcohol, known as the disulfiram reaction is usually enough to deter people from having another drink.
The disulfiram-alcohol reaction occurs within ten minutes of ingesting alcohol and may last for several hours. It can be potentially dangerous. For some people, knowing that they cannot drink alcohol without having this reaction is what is needed to prevent them from being tempted in a weak moment.
Avoid alcohol in disguised form, i.e., in sauces, vinegars, cough and cold mixtures, and aftershave lotions or liniments. You should also take care with low alcohol and non-alcohol or alcohol-free beers and wines, as these can also provoke a reaction when consumed in sufficient quantities.
If you miss a dose of Antabuse, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Store Antabuse in a cool, dry place, away from direct heat and light.
Anatabuse Precautions
• Tell your doctor your medical history, especially of heart, liver or kidney problems; diabetes, psychiatric problems and of any allergies you may have, especially to rubber or pesticides.
• This medication causes an intolerance to alcohol.
• Drinking alcohol while on this medication can cause serious effects that can last from 30 minutes to several hours.
• It produces an unpleasant reaction of flushing, headache, nausea, vomiting, dizziness, sweating, pounding heart (palpitations), blurred vision or weakness when even small amounts of alcohol are ingested.
• These disulfiram-alcohol reactions can occur up to two weeks after the medication has been stopped.
• Because disulfiram can cause drowsiness, use caution when driving or engaging in activities requiring alertness.
• Disulfiram should be used only when clearly needed during pregnancy.
• Discuss the risks and benefits with your doctor.
• It is not known if disulfiram is excreted into breast milk.
• Consult your doctor before breast-feeding.
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